Endocrine Abstracts

Introduction: Autoimmune polyglandular syndrome APS type 2 is a rare polygenic disease associationg endocrine autoimmune affection but also other auto immune diseases. The chronology is variable. We report in this context a case of APS associating a Hashimoto thyroiditis, a premature ovarian deficiency and an Addison disease revealed later.Case Report: A 33 year-old women consulted in 2018 for asthenia and spaniomennorrhea. The diagnosis of peripheral hy...

Introduction: The indications for anti-PD1 agents have expanded considerably in recent years, particularly for the treatment of melanoma, lung cancer and kidney cancer.Hypophysitis is a rare complication of anti-PD1 agents (< 1%) often with an atypical presentation, characterized by a later onset and a less symptomatic presentation.Case report: A 60-year-old woman was diagnosed with a clear cell renal carcinoma, treated with le...

Introduction: Sheehan syndrome (SS) is a hemorrhagic necrosis of the pituitary gland responsible of anterior pituitary insufficiency. It occurs in a context of cerebral hypo flow due to a rapid blood pressure drop and/or acute hemorrhagia. We report a case of SS revealed by acute corticotropic insufficiency.Case report: A sunday morning 34 years-old woman consulted the emergency department for of a fatigue and diarrhea. She reported a 7 kg weight-loss in...

Primary hyperparathyroidism is a frequent endocrine disorder but intrathyroidal parathyroid adenoma is extremely rare. Combining cervical ultrasound and MIBI scintigraphy allows localizing most parathyroid adenomas. Because intrathyroidal parathyroid adenomas mimic thyroid nodules the diagnosis can be challenging, requiring eventually the realization of a fine-needle cyto-puncture. We report here a case of an intrathyroidal parathyroid adenoma diagnosed via a combination of ce...

Introduction: Prolonged QT syndrome is defined as exceeding of the QT interval on the elecrocardiography (ECG) (> 450 ms in men and > 460 ms in women). It is either congenital or secondary to medication, electrolyte disturbances, heart disease. However, prolonged QT due to diabetic ketoacidosis (DKA) was rarely described. In this study, we tested the hypothesis that QTc prolongation occurs during DKA and returns to normal with resolution of ketosis.<p class="abstex...

Background: Multiple endocrine neoplasia (MEN) are rare and are characterized by the association of a neoplasia or hyperplasia of at least two endocrine glands. Rare cases of atypical MEN were reported in the literature. We describe a rare combination of acromegaly, papillairy thyroid carcinoma and primary hyperaldosteronism.Case presentation: We report a case of a 48-year old woman operated for papillary thyroid carcinoma. Five years later, sh...

Introduction: Androgenic insensitivity syndrome (AIS) is an X-linked genetic disease characterized by resistance to the actions of androgen in an individual with 46, XY karyotype. It is the most common cause of DSD in 46, XY individuals.Case report: We report a case of a 16-year-old girl who consulted for primary amenorrhea and hirsutism. Our patient had a 9-year-old sister who was operated for an inguinal hernia and the anathomopathological study conclu...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare disease, defined as a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This is an inherited disorder. However, sporadic cases account for 8–14%. We here report a case of MEN1 revealed by vitamin B12 deficiency.Observation: A 37-year-old young woman admitted to our department ...

Introduction: Thyroid ectopy is uncommon pathology. The lingual area is the most frequent localization. The medaistinal localization is rare. We report in this article two cases illustrating this location.1st clinical case66-year-old woman operated on for benign breast cysts consulted for progressive chest pain. The clinical examination was without abnormalities. The standard biological assessment was normal. Cervicothoracic CT sca...

Introduction: The association of thyroid nodules and connective tissue diseases (CTD) is not uncommon. The purpose of our work was to describe the clinical, biological and ultrasound characteristics of thyroid nodules during CTD.Materials and methods: It was a retrospective study (2015–2019) including records of patients with CTD and thyroid nodule in an internal medicine department at Ben Arous regional hospital. Informations regarding thyroid fun...